Fig. 4.

Cognitive decline continuum: from pathology to compensatory phenomena. Although SMC subjects show a different profile of functional connectivity pattern than MCI and healthy controls, synchronization changes are focused on the anterior, central, posterior and left temporal regions. MCI subject showed a hyper-synchronization (compensatory effect), whereas SMC a hypo-synchronization (the brain is not still compensating for the fails of the memory networks, being a pathological or dementia effect). AD patients show an impairment of their functional connectivity (Stam et al. 2009)