Fig. 1.

Example of magnetic resonance images analyzed in the study. A, B A slice from the T1-weighted MPRAGE series. C, D The same slice in the T2-weighted FLAIR series. In order to show the same anatomical level of the brain, the MR series acquired at baseline (A, C) were aligned to the series acquired at follow-up (B, D). Areas of WMH are outlined in red in the FLAIR images (C, D). Gray letters in the lower middle indicate: anterior (A), posterior (P), left (L), and right (R)