Table 2.
Longitudinal changes in total and regional WMH burden
| N = 77 | Baseline | Follow-up | Change |
|---|---|---|---|
| tWMH | 1.0 ± 0.9 (0.02, 4.2) | 1.5 ± 1.2 (0.04, 4.9)* | 0.4 ± 0.5 (−0.2, 2.1) |
| GCC-WMH | 6.0 ± 5.2 (0.1, 25.2) | 9.0 ± 5.8 (0.4, 23.8)* | 3.0 ± 3.3 (−2.6, 12.6) |
| BCC-WMH | 6.3 ± 6.3 (0, 31) | 9.5 ± 7.0 (0.3, 32.2)* | 3.2 ± 3.8 (−8.1, 14.4) |
| SCC-WMH | 1.9 ± 2.7 (0, 12.3) | 3.7 ± 4.5 (0, 19.8)* | 1.7 ± 3.3 (−3.4, 16.3) |
| ACR-WMH | 8.4 ± 8.9 (0, 53.2) | 13.4 ± 10.9 (0, 53.5)* | 5.0 ± 6.3 (−4.8, 30.9) |
| SCR-WMH | 8.1 ± 10.9 (0–60.8) | 14.7 ± 14.6 (0.1, 63.6)* | 6.5 ± 7.5 (−3.6, 40.2) |
| PCR-WMH | 23.5 ± 21.3 (0, 84) | 33.6 ± 24.4 (0, 91.5)* | 10.1 ± 13.0 (−15.4, 71.9) |
| SLF-WMH | 3.5 ± 6.8 (0, 35.4) | 6.7 ± 10.4 (0, 62.4)* | 3.2 ± 5.5 (−0.6, 31.6) |
Values represent percent: mean ± SD (min, max)
tWMH total WMH burden. Regional WMH burdens: in corpus callosum genu (GCC-WMH), body (BCC-WMH), and splenium (SCC-WMH); in corona radiata anterior (ACR-WMH), superior (SCR-WMH), and posterior (PCR-WMH); and in superior longitudinal fasciculus (SLF-WMH)
*p < 0.0001 (Wilcoxon, paired samples)