Table 3.
Correlation between changes in WMH burden and changes in mobility
| N = 77 | Balance standinga | Chair risea | Walk speeda | Tinetti gaita | Tinetti balancea |
|---|---|---|---|---|---|
| Age | −0.145 (>0.1) | −0.055 (>0.1) | −0.119 (>0.1) | −0.138 (>0.1) | −0.057 (>0.1) |
| BMI | 0.036 (>0.1) | −0.012 (>0.1) | 0.039 (>0.1) | 0.007 (>0.1) | −0.108 (>0.1) |
| Gender | −0.003 (>0.1) | −0.040 (>0.1) | −0.158 (>0.1) | 0.257 (0.026) | 0.039 (>0.1) |
| tWMHb | −0.045 (>0.1) | −0.381 (0.001) | −0.053 (>0.1) | −0.066 (>0.1) | 0.001 (>0.1) |
| GCC-WMHb | −0.083 (>0.1) | −0.297 (0.009) | 0.03 (>0.1) | 0.09 (>0.1) | 0.088 (>0.1) |
| BCC-WMHb | −0.053 (>0.1) | −0.384 (0.001)c | 0.019 (>0.1) | −0.212 (0.068) | −0.031 (>0.1) |
| SCC-WMHb | −0.228 (0.046) | −0.413 (0.0002)c | 0.002 (>0.1) | −0.116 (>0.1) | −0.087 (>0.1) |
| ACR-WMHb | 0.032 (>0.1) | −0.186 (>0.1) | −0.033 (>0.1) | −0.01 (>0.1) | 0.162 (>0.1) |
| SCR-WMHb | −0.056 (>0.1) | −0.300 (0.008) | −0.105 (>0.1) | −0.119 (>0.1) | −0.074 (>0.1) |
| PCR-WMHb | 0.004 (>0.1) | −0.247 (0.031) | 0.056 (>0.1) | 0.006 (>0.1) | −0.028 (>0.1) |
| SLF-WMHb | 0.04 (>0.1) | −0.140 (>0.1) | −0.095 (>0.1) | 0.033 (>0.1) | −0.087 (>0.1) |
Values represent Spearman’s correlation rho (p value). Significant correlations are highlighted in bold. Categorical variables: gender (men = 0, women = 1) and the mobility measures. All other variables are continuous. No significant correlations were observed with other mobility tests, i.e., usual walking velocity, self-paced maximum walking velocity, stair time, and turn time, and therefore are not shown
tWMH total WMH burden. Regional burdens: in corpus callosum genu (GCC-WMH), body (BCC-WMH), and splenium (SCC-WMH); in corona radiata anterior (ACR-WMH), superior (SCR-WMH), and posterior (PCR-WMH); and in superior longitudinal fasciculus (SLF-WMH)
aMobility measures (decline = 0, no-decline = 1)
bDifference = [follow-up − baseline]
cRemained significant after Bonferroni correction for multiple correlations (threshold p <0.007)