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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Int J Biochem Cell Biol. 2012 Jan 9;44(3):480–488. doi: 10.1016/j.biocel.2011.12.021

Figure 2. Diverse Functions of the SPARC Family of Proteins.

Figure 2

Schematic representation that highlights some of the activities attributed to each class of SPARC family members with a functional EC domain. SPARC family members are represented with ovals; red: SPARC, pink: Hevin/SPL1, magenta: Testican/SPOCK, purple: SMOC-1 and -2. Each family member is secreted and has been shown to affect some aspect of extracellular activity either through regulation of ECM assembly/degradation or through regulation of cell surface receptor/ligand interaction. In the case of Hevin/SPL-1 and SPARC this includes regulation of synapse formation via as yet unidentified factors either in the ECM and/or on cell surfaces. Collagen fibrils are shown in yellow with blue and orange rectangles representing the N and C-propeptides, respectively. KS: Killer signal (secreted by “winning” cells in Drosophila), DDR2: discoidin domain receptor 2, MT-MMP: membrane-type metalloproteinase, BMP: bone morphogenic protein, Ten C: tenascin C, MAPK: mitogen-associated protein kinase.