. Author manuscript; available in PMC: 2013 Mar 20.

Published in final edited form as: J Am Coll Cardiol. 2012 Mar 20;59(12):1101–1109. doi: 10.1016/j.jacc.2011.11.046

Table 3.

Multivariable Cox Proportional Hazard Models for Risk of Death or CVD per 1 Standard Deviation Increase in log₁₀NGAL and Other Biomarkers

	Cardiovascular Mortality		All-Cause Mortality		Combined Cardiovascular Endpoint^†
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
# of Deaths/Events	169		436		254
Unadjusted	1.72 (1.47–2.01)^**	<0.001	1.48 (1.34–1.64)^**	<0.001	1.48 (1.30–1.69)^**	<0.001
Model 1	1.34 (1.15–1.58)^**	<0.001	1.22 (1.10–1.35)^**	<0.001	1.29 (1.13–1.47)^**	<0.001
Model 2	1.33 (1.12–1.57)^*	0.001	1.19 (1.07–1.32)^*	0.001	1.26 (1.10–1.45)^*	0.001
Model 3
NGAL	1.25 (1.05–1.48)	0.01	1.14 (1.03–1.28)	0.02	1.21 (1.05–1.39)	0.01
NT-proBNP	1.80 (1.48–2.18)^**	<0.001	1.42 (1.26–1.61)^**	<0.001	1.52 (1.29–1.79)^**	<0.001
CRP	1.09 (0.90–1.31)	0.38	1.06 (0.95–1.19)	0.29	1.08 (0.93–1.26)	0.31

Model 1 - Adjusted for age and sex.

Model 2 - Adjusted for Model 1 + diabetes, hypertension, and current smoking (dichotomous variables) and systolic blood pressure, total cholesterol, HDL, creatinine clearance, and body mass index.

Model 3 - Adjusted for Model 2 + log₁₀NT-proBNP and log₁₀CRP.

Bold values are significant at p<0.05.

values are significant at p<0.01.

^**

values are significant at p<0.001.

^†

Combined Cardiovascular Endpoint = coronary revascularization, myocardial infarction, or CVD death.

CI = confidence interval; HR = hazard ratio.