Table 2.
List of the VOCs obtained from the tumor-bearing mice that were increased or decreased relative to the control group.
| Increased compound | CAS No. | Classification | fold | p-value |
|---|---|---|---|---|
| 1,3-Di-tert-butylbenzene | 1014-60-4 | ethers | + | 0.08 |
| 2-(sec-butyl)-4,5-dihydrothiazole | 56367-27-2 | sulfurs | ++ | 0.01 |
| 2,4-Dimethylheptane | 2213-23-2 | hydrocarbons | + | < 0.01 |
| 2,5-Dimethylpyrazine | 123-32-0 | pyrazines | + | 0.07 |
| 2,5-Heptanedione | 1703-51-1 | ketones | + | 0.03 |
| 2-Acetyl-5-methylfuran | 1193-79-9 | furans | + | 0.02 |
| 2-Aminobenzamide | 88-68-6 | aldehydes | + | 0.05 |
| 2-Butanone | 78-93-3 | ketones | + | 0.02 |
| 2-Ethyl-5-methylfuran | 1703-52-2 | furans | + | 0.06 |
| 2-Heptanone | 110-43-0 | ketones | + | 0.04 |
| 2-Hexanone | 591-78-6 | ketones | + | 0.03 |
| 2-Methoxy-5-methylthiophene | 31053-55-1 | sulfurs | + | 0.02 |
| 2-Methylfuran | 534-22-5 | furans | ++ | 0.01 |
| 2-Methylpyrazine | 109-08-0 | pyrazines | ++ | 0.07 |
| 2-Pentanone | 107-87-9 | ketones | + | 0.09 |
| 2-Methyl-6-vinylpyrazine | 13925-09-2 | pyrazines | ++ | 0.02 |
| 3-Hexanone | 589-38-8 | ketones | + | 0.1 |
| 3-Methyl-1-hexen-3-ol | 55145-28-3 | alcohols | ++ | 0.01 |
| 4-Heptanone | 123-19-3 | ketones | + | 0.03 |
| 4-Ketoisophorone | 1125-21-9 | ketones | + | 0.05 |
| 4-Methoxyphenol | 150-76-5 | phenols | + | 0.02 |
| 4-Methyloctane | 2216-34-4 | hydrocarbons | + | 0.02 |
| 5-Hepten-2-one | 6714-00-7 | ketones | + | 0.04 |
| 6-methyl-3-heptanone | 624-42-0 | ketones | + | 0.03 |
| Acetone | 67-64-1 | ketones | + | 0.03 |
| Acetophenone | 98-86-2 | ketones | + | 0.03 |
| Benzaldehyde | 100-52-7 | aldehydes | + | 0.03 |
| Dimethyl succinate | 106-65-0 | esters | + | 0.05 |
| Dimethyl trisulfide | 3658-80-8 | sulfurs | + | 0.04 |
| Dimethylamine | 124-40-3 | amines | +++ | 0.1 |
| exo-Brevicomin | 20290-99-7 | ethers | + | 0.03 |
| gamma-Crotonolactone | 497-23-4 | esters | + | 0.05 |
| gamma-Hexanolactone | 695-06-7 | esters | + | 0.02 |
| Maltol | 118-71-8 | pyrans | + | 0.02 |
| N,N-Dimethylacetamide | 127-19-5 | amines | + | 0.08 |
| N-Benzylidenemethylamine | 622-29-7 | amines | +++ | 0.06 |
| Phenol | 108-95-2 | phenols | + | 0.01 |
| Phenylacetone | 103-79-7 | ketones | + | 0.07 |
| p-Toluidine | 106-49-0 | amines | + | 0.03 |
| Pyrazinamide | 98-96-4 | amides | + | 0.01 |
| Quinazoline | 253-82-7 | Quinazolines | +++ | 0.07 |
| Trimethylamine | 75-50-3 | amines | + | 0.02 |
| Decreased compound | CAS No. | Classification | fold | p-value |
| 4-Methyl-6-hepten-3-one | 26118-97-8 | ketones | -- | < 0.01 |
This table shows the VOCs, which were significantly different (p < 0.10) and more than 1.5 fold different to the averaged peak area (n = 3). The fold change indicates the difference in the averaged peak area between the tumor-bearing mice and normal control mice (+++ > 3 fold increase, ++ > 2 fold increase, + > 1.5 fold increase, --- < 3 fold decrease, -- < 2 fold decrease, - < 1.5 fold decrease).