Table 2. Genotype distributions of 4 SNPs in COL18A1 gene of the 302_Beijing samples.

			Allele, n (%)			Genotype, n (%)		Cochran Armitage trend test	logistic regression#
	1/2	1	2	P/OR (95% CI)	11	12	22	P	P/OR (95% CI)
rs2183589	C/T
HCC (n = 169)		306 (90.5%)	32 (9.5%)	0.18	139 (82.2%)	28 (16.6%)	2 (1.2%)	0.18	0.20
CHB (n = 203)		355 (87.4%)	51 (12.6%)	1.37 (0.86–2.19)	155 (76.4%)	45 (22.2%)	3 (1.5%)		1.37 (0.85–2.22)
rs2230688	G/T
HCC (n = 169)		223 (66.0%)	115 (34.0%)	0.43	72 (42.6%)	79 (46.7%)	18 (10.7%)	0.43	0.41
CHB (n = 203)		279 (68.7%)	127 (31.3%)	0.88 (0.65–1.20)	99 (48.8%)	81 (39.9%)	23 (11.3%)		0.88 (0.64–1.20)
rs11702425	T/C
HCC (n = 169)		262 (77.5%)	76 (22.5%)	0.98	104 (61.5%)	54 (32.0%)	11 (6.5%)	0.98	0.73
CHB (n = 203)		315 (77.6%)	91 (22.4%)	0.99 (0.70–1.41)	127 (62.6%)	61 (30.0%)	15 (7.4%)		0.94 (0.67–1.32)
rs7499	C/T
HCC (n = 169)		153 (45.3%)	185 (54.7%)	0.006	29 (17.2%)	95 (56.2%)	45 (26.6%)	0.005	0.009
CHB (n = 203)		225 (55.4%)	181 (44.6%)	0.67 (0.50–0.89)	63 (31.0%)	99 (48.8%)	41 (20.2%)		0.66 (0.48–0.90)

^#P values were adjusted for age, gender, smoking and drinking by binary logistic regression.