Table 4. Association results for rs7499 in replication studies.

		Allele, n (%)			Genotype, n (%)		Cochran Armitage trend test	logistic regression#
	C	T	P/OR (95% CI)	CC	CT	TT	P	P/OR (95% CI)
Youan_Beijing
HCC (n = 326)	297 (45.6%)	355 (54.4%)	0.003	63 (19.3%)	171 (52.5%)	92 (28.2%)	0.003	0.29
CHB (n = 522)	552 (52.9%)	492 (47.1%)	0.75 (0.61–0.91)	151 (28.9%)	250 (47.9%)	121 (23.2%)		0.88 (0.70–1.11)
Guangxi
HCC (n = 313)	237 (37.9%)	389 (62.1%)	0.01	41 (13.1%)	155 (49.5%)	117 (37.4%)	0.01	0.01
CHB (n = 342)	307 (44.9%)	377 (55.1%)	0.75 (0.60–0.93)	70 (20.5%)	167 (48.8%)	105 (30.7%)		0.75 (0.60–0.94)
Combined*
HCC (n = 808)	687 (42.5%)	929 (57.5%)	5e-7	133 (16.5%)	421 (52.1%)	254 (31.4%)	4e-7	0.00001
CHB (n = 1067)	1084 (50.8%)	1050 (49.2%)	0.72 (0.63–0.82)	284 (26.6%)	516 (48.4%)	267 (25.0%)		0.73 (0.64–0.84)

^#P values were adjusted for age, gender, smoking and drinking by binary logistic regression.

^*Combination of 3 case-control samples from 302_Beijing, Youan_Beijing and Guangxi.