Table 4.
Multivariate COX regression analyses for overall survival in invasive epithelial ovarian cancer (TOV) patients
| B | Wald | p-value | HR | 95% CI | ||
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| Univariate analyses1 | ||||||
| C282Y mutation (WT/WT)2 | – | 15.442 | 0.001 | – | – | – |
| C282Y mutation (WT/Y)2 | −2.378 | 10.677 | 0.001 | 0.093 | 0.022 | 0.386 |
| C282Y mutation (Y/Y)2 | −1.544 | 3.926 | 0.048 | 0.213 | 0.046 | 0.983 |
| H63D mutation (WT/WT)2 | – | 3.681 | 0.159 | – | – | – |
| H63D mutation (WT/D)2 | −0.712 | 2.307 | 0.129 | 0.491 | 0.196 | 1.230 |
| H63D mutation (D/D)2 | −0.975 | 3.653 | 0.056 | 0.377 | 0.139 | 1.025 |
| Age | 0.026 | 6.413 | 0.011 | 1.026 | 1.006 | 1.047 |
| Grade | 0.468 | 6.258 | 0.012 | 1.597 | 1.107 | 2.306 |
| Stage | 0.827 | 16.738 | <0.001 | 2.287 | 1.539 | 3.399 |
| Multivariate analyses3 | ||||||
| Age | 0.028 | 7.469 | 0.006 | 1.029 | 1.008 | 1.050 |
| Stage | 0.817 | 15.862 | <0.001 | 2.263 | 1.514 | 3.384 |
| C282Y mutation (WT/WT)2 | – | 16.149 | <0.001 | – | – | – |
| C282Y mutation (WT/Y) | −2.279 | 9.603 | 0.002 | 0.102 | 0.024 | 0.433 |
| C282Y mutation (Y/Y) | −1.281 | 2.687 | 0.101 | 0.278 | 0.060 | 1.285 |
HR: hazard ratio.
1
Univariate COX regression analyses using the ENTER model.
2
Categorical variable.
3
Multivariate COX regression analyses using the Forward-Wald model.