Table 1.
Ovarian cancer-associated proteins.
| Biological function | Biomarkers | Role in cancer |
|---|---|---|
| Cytokines/chemokines | IL-1, -6, -7, -8, -10, -11, -12, -16, -18, -21, -23, -28A, -33, LIF, TNFR1–2, HVEM (TNFRSF14), IL1R-a, IL1R-b, IL-2R, M-CSF, MIP-1a, TNF-α, CD40, RANTES, CD40L, MIF, IFN-β, MCP-4 (CCL13), MIG (CXCL9), MIP-1δ (CCL15), MIP3a (CCL20), MIP-4 (CCL18), MPIF-1, SDF-1a + b (CXCL12), CD137/4–1BB, lymphotactin (XCL1), eotaxin-1 (CCL11), eotaxin-2 (CCL24), 6Ckine/CCL21), BLC (CXCL13), CTACK (CCL27), BCA-1 (CXCL13), HCC4 (CCL16), CTAP-3 (CXCL7) | Tumor growth, angiogenesis, immune functions, inflammation, invasion |
| Growth/angiogenic factors | IGF1, VEGF, VEGFR3, EGFR, ErbB2, CTGF, PDGF AA, BB, PDGFRb, bFGF, TGFbRIII, β-cellulin, IGFBP1–4, 6, BDNF, PEDF, angiopoietin-2, renin, lysophosphatidic acid, β2-microglobulin, sialyl TN, ACE | Tumor growth, angiogenesis |
| Adhesion molecules/proteases/related molecules | CA-125, CA 19–9, CEA, CA 15–3, CA-50, CA 72–4, OVX1, mesothelin, sialyl TN, MMP-2, -3, -7, -9, VAP-1, TIMP1–2, tenascin C, VCAM-1, osteopontin, KIM-1, NCAM, tetranectin, nidogen-2, cathepsin L, prostasin, matriptase, kallikreins 2, 6, 10, cystatin C, claudin, spondin2, SLPI | Invasion/metastases |
| Hormones/related molecules | bHCG, urinary gonadotropin peptide, inhibin, leptin, adiponectin, GH, TSH, ACTH, PRL, FSH, LH, cortisol, TTR, osteocalcin, insulin, ghrelin, GIP, GLP-1, amylin, glucagon, peptide YY, follistatin, hepcidin | Tumor growth, transformation |
| Acute-phase reactants/coagulation factors | CRP, Apo A1, CIII, H, transthyretin, SAA, SAP, complement C3,4, complement factor H, albumin, ceruloplasmin, haptoglobin, β-hemoglobin, transferrin, ferritin, fibrinogen, thrombin, von Willebrand factor, myoglobin, immunosuppressive acidic protein, lipid- associated sialic acid, S100A12 (EN-RAGE), fetuin A, clusterin, α1-antitrypsin, a2- macroglobulin, serpin1 (human plasminogen activator inhibitor-1), Cox-1, Hsp27, Hsp60, Hsp80, Hsp90, lectin-type oxidized LDL receptor 1, CD14, lipocalin 2, ITIH4 | Inflammation, tumor growth, angiogenesis |
| Apoptosis factors | sFasL, Cyfra21–1, TPA, perforin, DcR3 | Tumor growth, immune functions |
| Energy homeostasis | AGRP, creatine kinase-MB | Tumor growth |
| Proteins with undefined or other functions | HE4, human milk fat globule 1–2, NT-Pro-BNP, neuron-specific enolase, CASA, NB/70K, AFP, afamin, collagen, prohibitin, keratin-6, PARC, B7-H4, YK-L40 |