Table 3.

Physiological networks associated with ovarian cancer biomarkers.

Network	Biomarkers in network	Score	Top functions
1	A2M, adipokine, angiopoietin, APOA1, APOH, SAP, C3, CCL4, CCL5, CCL11, CCL13, CCL15, CCL18, CCL20, CCL21, CCL24, CCL27, CD14, CD40, CD40L, creatine kinase, CRP, CTGF, CXCL9, CXCL13, EGFR, Erbb2, eotaxin, ferritin, fibrin, fibrinogen, GH, hemoglobin, IFN-β, IGF1, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL-1, IL-6, IL-8, IL-10, IL-23, IL-33, IL-1R, IL-12, IL-17, IL-1R1, IL-23A, inhibin, LIF, LPA, MIF, MMP-2, MMP-3, MMP-7, MMP-9, PYY, S100A12, SAA, SAA1, tPAI1, Tenascin, TGF-β, TIMP1, TIMP2, TNF, TNFR1 and 2, TTR, VCAM1, XCL1	115	Cellular movement, hematological system development and function, immune cell trafficking
2	BDNF, CEA, EGFR, ErbB2, FSH, ghelin, GIP, hCG, IL-7, IL-16, IL-2R, IL-2R, insulin, integrin, KLK6, NCAM1, PDGF-BB, PDGF-AA, PRL, TNF, TSH, VEGF, VWF, clusterin, β-cellulin, albumin, glucagon, casein, tansferrin, tenascin C, CXCL12, thrombin, FasL, KIM-1, MFG8	46	DNA replication, recombination and repair
3	Afamin, AGRP, APOC3, CCL13, CCL27, CKB, HGF, IL-6, IL-17, KLK2, KLK11, MUC16, PDGF-DD, complement factor H, AHSG, claudin, collagen, cathepsin D, leptin, mesothelin, nidogen 2, α-antitrypsin, HE4	22	Cell cycle, inflammatory response