Table 2.
Clinical features and prevalence of hepatitis C virus-positive patients in low grade B-lymphoma series
| Author | Year | HCV-positive patients number | Histology | Study type | Clinical features of HCV-positive1 |
| Arcaini et al[19] | 2006 | 49 (15%) out of 309 | SMZL | Retrospective series analysis | B-symptoms |
| Female prevalence | |||||
| Abdominal lymph nodes | |||||
| Villous lymphocytes | |||||
| Monoclonal component | |||||
| Cryoglobulin | |||||
| Ferreri et al[12] | 2006 | 7 (12%) out of 55 | OAL of the MALT type | Retrospective series analysis | Advanced extra-orbital disease |
| Lymph node dissemination | |||||
| Involvement of other extranodal organs | |||||
| Worse progression free survival | |||||
| Arcaini et al[23] | 2007 | 9 (19%) out of 47 | Nodal MZL | Retrospective series analysis | Advanced stage |
| B-symptoms | |||||
| Cryoglobulin | |||||
| Arcaini et al[30] | 2006 | 60 (35%) out of 172 | Non-gastric MALT | Retrospective series analysis | Single MALT site |
| Older age | |||||
| Female prevalence | |||||
| Less frequent marrow involvement | |||||
| Strianese et al[24] | 2010 | 23 (18%) out of 129 | OAL | Retrospective series analysis | More widespread disease at the onset |
1
Clinical features with statistical relevance compared to hepatitis C virus (HCV)-negative patients. OAL: Ocular adnexal lymphoma; MZL: Marginal zone lymphoma; SMZL: Splenic MZL.