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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Trends Endocrinol Metab. 2012 Feb 28;23(4):179–185. doi: 10.1016/j.tem.2012.01.002

Figure 1. A model depicting hypothalamic-mediated control of metabolic homeostasis.

Figure 1

AgRP and POMC neurons in the hypothalamic arcuate nucleus (ARH) and SF1 neurons in the ventromedial hypothalamic nucleus (VMH) are able to detect fluctuations in circulating levels of metabolic cues (e.g.: leptin and glucose) and to coordinate responses (e.g.: changes in food intake, energy expenditure, glucose production from the liver and glucose uptake by the skeletal muscle) aimed at maintaining normal body weight and glucose balance. Depicted are also projections from AgRP and VMH neurons to POMC neurons.