Table 2.

Association of HO-1 promoter genotypes with the risk of CHD at three levels of oxidative stress

Levels of oxidative stress	Case	Control	Age-adjusted OR	P value	Adjusted ORa	P value
	No. (%)	No. (%)
Overall	2,298 (100.0)	2,298 (100.0)
Genotype
L/L	594 (25.8)	563 (24.5)	1.00	–	1.00	–
S/L	1,268 (55.2)	1,187 (51.7)	1.046 (0.930–1.176)	0.457	1.07 (0.913–1.248)	0.412
S/S	436 (19.0)	548 (23.8)	0.844 (0.731–0.975)	0.021	0.798 (0.659–0.965)*	0.020
Alleles
L	2,456	2,313	1.00	–
S	2,140	2,283	0.88 (0.81–0.96)	–
					Pbinteraction	0.002*
Low level
Genotype
L/L	155 (24.6)	200 (26.1)	1.00	–	1.00	–
S/L	328 (52.1)	394 (51.4)	1.069 (0.827–1.813)	0.611	1.148 (0.860–1.532)	0.349
S/S	146 (23.2)	173 (22.6)	1.086 (0.800–1.473)	0.597	1.056 (0.749–1.491)	0.755
Alleles
L	638	794	1.00	–	–
S	620	740	1.04 (0.89–1.20)	–	–
Intermediate level
Genotype
L/L	193 (27.1)	205 (26.8)	1.00	–	1.00	–
S/L	412 (57.9)	401 (52.4)	1.087 (0.855–1.382)	0.494	1.114 (0.847–1.466)	0.441
S/S	107 (15.0)	159 (20.8)	0.715 (0.522–0.979)	0.036*	0.787 (0.551–1.123)	0.186
Alleles
L	798	811	1.00	–	–	–
S	626	719	0.88 (0.77–1.02)	–	–	–
High level
Genotype
L/L	245 (25.6)	158 (19.9)	1.00	–	1.00	–
S/L	524 (54.8)	393 (51.3)	0.858 (0.675–1.090)	0.210	0.912 (0.702–1.185)	0.491
S/S	188 (19.6)	215 (28.5)	0.563 (0.425–0.745)	<0.001*	0.595 (0.438–0.809)	0.001*
Alleles
L	1,014	709	1.00	–	–	–
S	900	823	0.75 (0.66–0.86)	–	–	–

*P < 0.05

^aAdjusted for age, gender, smoking, hypertension, BMI, and diabetes

^bValue is P interaction between HO-1 gene promoter genotypes and levels of oxidative stress