Table 2.
Genotype Frequency
| Single Nucleotide Polymorphisms | All Patients (n=136) |
Grade 0-1 RP (n=96) |
≥Grade 2 RP (n=40) |
≥Grade 3 RP (n=19) |
|---|---|---|---|---|
|
| ||||
| MTHFR (rs1801131)* | ||||
| AA | 61 (45.5%) | 38 (40.0%) | 23 (59.0%) | 13 (72.2%) |
| AC | 60 (44.8%) | 48 (50.5%) | 12 (30.8%) | 3 (11.1%) |
| CC | 13 (9.7%) | 9 (9.5%) | 4 (10.3%) | 2 (16.7%) |
| AC/CC | 73 (54.5%) | 57 (60.0%) | 16 (41.0%) | 5 (27.8%) |
|
| ||||
| MTHFR (rs1801133)* | ||||
| CC | 51 (38.1%) | 40 (42.1%) | 11 (28.2%) | 4 (22.2%) |
| CT | 59 (44.0%) | 40 (42.1%) | 19 (48.7%) | 8 (44.4%) |
| TT | 24 (17.9%) | 15 (15.8%) | 9 (23.1%) | 6 (33.3%) |
| CT/ TT | 83 (61.9%) | 55 (57.9%) | 28 (71.8%) | 14 (77.7%) |
|
| ||||
| SOD2 (rs4880) | ||||
| TT | 32 (23.5%) | 21 (21.9%) | 11 (27.5%) | 6 (31.6%) |
| TC | 76 (55.9%) | 51 (53.1%) | 25 (62.5%) | 9 (47.4%) |
| CC | 28 (20.6%) | 4 (25.0%) | 4 (10%) | 4 (21.0%) |
| TC/CC | 104 (76.5%) | 72 (78.1%) | 29 (72.5%) | 13 (68.4%) |
*
Data available on 134 patients
Abbreviations: RP=radiation pneumonitis.