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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Cancer. 2011 Dec 5;118(14):3654–3665. doi: 10.1002/cncr.26667

Table 2.

Genotype Frequency

Single Nucleotide Polymorphisms All Patients
(n=136)
Grade 0-1 RP
(n=96)
≥Grade 2 RP
(n=40)
≥Grade 3 RP
(n=19)

MTHFR (rs1801131)*
AA 61 (45.5%) 38 (40.0%) 23 (59.0%) 13 (72.2%)
 AC 60 (44.8%) 48 (50.5%) 12 (30.8%) 3 (11.1%)
 CC 13 (9.7%) 9 (9.5%) 4 (10.3%) 2 (16.7%)
AC/CC 73 (54.5%) 57 (60.0%) 16 (41.0%) 5 (27.8%)

MTHFR (rs1801133)*
CC 51 (38.1%) 40 (42.1%) 11 (28.2%) 4 (22.2%)
 CT 59 (44.0%) 40 (42.1%) 19 (48.7%) 8 (44.4%)
 TT 24 (17.9%) 15 (15.8%) 9 (23.1%) 6 (33.3%)
CT/ TT 83 (61.9%) 55 (57.9%) 28 (71.8%) 14 (77.7%)

SOD2 (rs4880)
TT 32 (23.5%) 21 (21.9%) 11 (27.5%) 6 (31.6%)
 TC 76 (55.9%) 51 (53.1%) 25 (62.5%) 9 (47.4%)
 CC 28 (20.6%) 4 (25.0%) 4 (10%) 4 (21.0%)
TC/CC 104 (76.5%) 72 (78.1%) 29 (72.5%) 13 (68.4%)
*

Data available on 134 patients

Abbreviations: RP=radiation pneumonitis.