Table 1.
Genes that comprise a genetic signature of pathogenic immune responses associated with the development of CVB4-V-induced chronic pancreatitis.
| GENE | FUNCTION |
|---|---|
| Toll-like receptors | |
| Tlr2 | Cell surface expression. Binds lipopeptides |
| Tlr4 | Cell surface expression. Binds LPS |
| Tlr5 | Cell surface expression. Binds proteins |
| Tlr7 | Endosomal expression. Binds ssRNA |
| Tmed1/st2l | Modulates innate immunity by inhibiting TLR signaling |
| TH17 responses | |
| Il6ra | IL-6 receptor subunit |
| Il6st/gp130 | IL-6 receptor subunit |
| Tgfb1 | TGF-β and IL-6 promote TH17 responses |
| Il17rb | IL-17 receptor |
| Il8ra | Receptor for IL-8/CXCL8 expressed on neutrophils |
| Tnfa | Proinflammatory cytokine produced by macrophages and DCs |
| Iltifb/Il22b | TH17 cytokine |
| RORγt | Transcription factor for TH17 cells |
| TH1 responses | |
| Socs5 | Inhibits IL-4 signaling. Promotes TH1 responses |
| Ebi3/IL-27B | Subunit of IL-27. Promotes TH1 responses |
| Ccl3/Mip1a | Recruits activated T cells, NK, NKT, and macrophages. Promotes TH1 responses |
| Ccr5 | Receptor for CCL3, CCL4, and CCL5. Promotes TH1 responses |
| Ifngr1 | Receptor for IFN-γ |
| Ifng | TH1 cytokine |
| Cxcr3 | Receptor for CXCL9, CXCL10, and CXCL11. Promotes TH1 responses |
| Cxcl10/IP10 | Chemotactic for T cells and monocytes |
| Tbet/Tbx21 | Transcription factor for TH1 cells |
| Other | |
| Gata3 | Transcription factor for TH2 cells |
| Socs3 | Involved in multiple signaling pathways. Inhibits JAK-STAT pathways |
| Il10 | Regulatory cytokine. Generally considered anti-inflammatory |