Table 3.
ID | Molecules in subnetwork | Scorea) | Number of focus moleculesb) | Top functions |
---|---|---|---|---|
1 | ACTA1c), ACTA2, ACTB, ACTC1, ACTG1, ACTG2, Actin, Alpha actin, Alpha Actinin, Alpha catenin, atypical protein kinase C, Cadherin, CASP1, CASP3, ERK1/2, Fgf, G-Actin, Hsp27, Hsp90, Ige, JUP, KAT5, OSBP, PFN1, Phosphatidylinositol4,5 kinase, Pld, PP2A, Profilin, RAB9A, Ras homolog, Rho gdi, RHOC, RhoGap, Rock, Rsk | 29 | 14 | Cell Death, Cellular Assembly and Organization, Skeletal and Muscular System Development and Function |
2 | 14-3-3, Alcohol group acceptor phosphotransferase, BAG5, BCR, Caspase, CD3, Cdc2, CDC42, DSP, Ephb, EXOC7, F Actin, Fcer1, Filamin, FLNA, IQGAP, IQGAP1, KRT8, KRT18, Laminin, MAP2K4, MAP2K7, MAP2K4/7, MAP3K, Mek, NFkB (complex), Pak, Pkg, PKN1, Raf, Rap1, Sapk, TCR, TXN, VAV | 24 | 12 | Cellular Assembly and Organization, Gastrointestinal Disease, Genetic Disorder |
3 | 26s Proteasome, AIP, Akt, APC/APC2, Calmodulin, Cbp/p300, Ck2, CTNNB1, DNAJB11, FSH, Gpcr, hCG, Histone h3, Histone h4, Hsp70, Ifn gamma, IgG, Ikb, IL12 (complex), Insulin, Interferon alpha, Jnk, Lh, Pka, PLC, PLS3, RNA polymerase II, TP53, UBB, UBC, UBE2D1, UBE2L3, Ubiquitin, VCP, YWHAG | 20 | 11 | Cancer, Cellular Development, Cellular Growth and Proliferation |
4 | AMPK, Ap1, Calpain, Collagen type I, Collagen type IV, ERK, Estrogen Receptor, Fibrinogen, Focal adhesion kinase, G protein beta gamma, Gef, IFN Beta, IL1, Integrin, LDL, Mapk, MAPK1, NFKBIA, P38 MAPK, p85 (pik3r), Pdgf (complex), PDGF BB, PI3 K (complex), Pkc(s), RAB5A, RAB7A, Rac, RAC1, Ras, RHOA, STAT5a/b, Tgf beta, TLN1, TRIP6, Vegf | 14 | 8 | Cardiovascular System Development and Function, Cell-To-Cell Signaling and Interaction, Cell Signaling |
5 | AFAP1L2, AGT, AKIRIN2, ARL6, ARL4C, BUB3, C11orf1, CAPRIN1, CES2, COX7A2, GIPC2, HNF4A, HNRNPA0, HOOK3, IL6, IRF6, LPP, MRPL44, NIPSNAP3A, POLR3G, PRCP, PTK2, PTK7, REG1A, SBNO2, SETDB1, SLC14A2, SLC16A6, SUGT1, TDO2, TXNDC9, UBA52, UTP3, XPNPEP2, ZFP64 | 10 | 6 | Increased Levels of CRPd), Cell Morphology, Cellular Development |
Scores were log-transformed by the P-values, which were calculated by Fisher’s exact test.
The number of focus molecules is the number of the genes with the bold font.
The genes with the bold front are these genes existed in our gene set.
CRP is abbreviated for c-reactive protein.