Table 1.
Sex Differences in murine survival following viral infections
| virus (strain)a | routeb | inoculum dose |
mouse strain |
greater mortality |
survival females |
survival males |
reference |
|---|---|---|---|---|---|---|---|
| SLE virus (CDC-904) | i.v. | 107 SMLD50 | Ha/ICR | males | 50% (38/76) | 32% (24/76) | [62] |
| EMCV | i.p. | 104.3 TCID50 | Swiss | males | 52% (27/52) | 12% (6/52) | [63] |
| ectromelia (Moscow) | s.q. | 105 &107 pfu | DBA/2×(B6×D2)F1 | females | 82% (56/68) | 51% (36/70) | [64] |
| HSV-1 (strain F) | c.s. | 105–107 pfu | 129 sv/Ev | males | 92% (23/25) | 77% (115/150) | [51] |
| HSV-1 (strain 17) | c.s. | 10× LD50 | 129×(B6×129)F1 | males | 68% (89/131) | 52% (75/144) | [65] |
| HSV-1 (strain VR) | i.n. | 1.2×105 pfu | CD-1 | males | 84% (37/44) | 72% (31/43) | [52] |
| influenza A (PR8) | i.n. | 102 TCID50 | B6 | females | 0% (0/15) | 47% (7/15) | [7] |
| influenza A (PR8) | i.n. | 102 TCID50 | B6 | females | 0% (0/10) | 50% (5/10) | [14] |
| coxsackievirus (H3) | i.p. | 100 pfu | B6 | males | 100% (10/10) | 50% (5/10) | [14] |
a
SLE- St Louis encephalitis virus; EMCV – encephalomyocarditis virus
b
i.v. – intravenous injection; i.p. – intraperitoneal injection; i.n. – intranasal injection; c.s. – corneal scarification; s.q. – subcutaneous injection