Table 1. Overview of Dosing Trials in Aki.

		Study Design & Location	No. of patients		RRT Modality	Replacement Solution & Administration		Dose calculation & Prescribed dose
Continuous renal replacement therapy trials
Ronco et al13		single center RCT; Italy	425		CVVH	Lactate; Post-filter		Effluent flow rate; 20mL/kg/hr vs. 35mL/kg/hr vs. 45 mL/kg/hr
Bouman et al15		2 center RCT; The Netherlands	106		CVVH	Bicarbonate; Post-filter		Effluent flow rate; 19 mL/kg/hr vs. 48mL/kg/hr
Saudan et al16		single center RCT; Switzerland	206		CVVH /CVVH DF	Lactate and bicarbonate; Post-filter		Effluent flow rate; CVVH – 25mL/kg/hr CVVHDF – 42mL/kg/hr
Tolwani et al17		single center RCT; USA	200		CVVHD F	Bicarbonate; Pre-filter		Effluent flow rate; 20mL/kg/hr vs. 35mL/kg/hr
Bellomo et al19		multicenter RCT; Australia, NZ	1,508		CVVHD F	Bicarbonate; Post-filter		Effluent volume; 25mL/kg hr vs. 40mL/kg/hr
Intermittent hemodialysis trial
Schiffl et al14		single center Alt Assign,; Germany	160		IHD	NA		Kt/Vurea and frequency of IHD; Kt/Vurea of 1.2 per IHD every other day vs daily
Extended dialysis trial
Faulhaber-Walter et al20		multicenter RCT; Germany	156		ED	NA		Plasma urea level 120-150 mg/dl vs. <90 mg/dl
Combination modality trial
Palevsky et al18	multicenter RCT; USA			1,124	IHD, SLED, CVVHD F	Bicarbonate; Pre-filter	Kt/Vurea and Effluent volume; Kt/Vurea of 1.3 in IHD and SLED – 3 vs. 6 times/wk;Effluent Volume, 20mL/kg/hr vs. 35mL/kg/hr

Alt Assign – alternate assignment; CVVH – continuous venovenous hemofiltration; CVVHDF – continuous venovenous hemodiafiltration; ED – extended dialysis; SLED – sustained low efficiency dialysis; IHD – intermittent hemodialysis; NA -- Not applicable; RCT – randomized controlled trial; All trials controlled for severity of illness using APACHE II or III or SOFA scoring.