Table 5.
Haplotype estimation analysis of investigated polymorphisms within CTLA-4 gene
| CTLA-4c.49A>G/ | Multiple myeloma n = 200 | Controls group n = 380 | OR | 95%CI | p | p after Bonferroni correction |
|---|---|---|---|---|---|---|
| CTLA-4g.319C>T/ | ||||||
| CTLA-4g.*642AT (8-32)/ | ||||||
| CT60 G>A/ | ||||||
| Jo31 G>T | ||||||
| A C 8 A T | 97.72 (0.28) | 256.28 (0.36) | 0.70 | [0.53 ~ 0.94] | 0.02 | 0.1 |
| A C >8 G G | 22.61 (0.07) | 36.35 (0.05) | 1.33 | [0.78 ~ 2.29] | 0.30 | |
| A T >8 G G | 24.02 (0.07) | 50.04 (0.07) | 1.01 | [0.61 ~ 1.68] | 0.97 | |
| G C 8 A T | 16.54 (0.05) | 17.21 (0.03) | 2.08 | [1.04 ~ 4.14] | 0.03 | 0.15 |
| G C 8 G G | 30.33 (0.09) | 18.17 (0.03) | 3.79 | [2.08 ~ 6.89] | 3.67e-006 | 1.0e-005 |
| G C >8 G G | 111.33 (0.32) | 257.64 (0.37) | 0.854 | [0.64 ~ 1.13] | 0.27 |
Global result:
Total control = 700.0, total case = 346.0, Global chi2 is 29.923019 while df = 5, Fisher’s p value is 1.58e-005, pafter Bonferroni correction = 7.5e-005