Figure 1.

Schematic representation of HIF regulation of erythropoiesis. Gray boxes represent genome scan-nominated candidate genes that have been hypothesized to contribute to the blunted erythropoietic response in Tibetans. The genes in the white boxes are provided for reference. Note that for simplicity, many other genes that participate in erythropoiesis (for example, hepcidin, ferroportin, transferrin and Janus kinase) have been omitted. Figure modified from those in Semenza (2009) and Simonson et al. (2010).