Figure 2.

Differentiating between specific and non-specific drug synergies. Comparing drug–target interactions with synthetic genetic interactions provides information on specific and non-specific drug synergies. For example, Drug 1 and Drug 3 exhibit specific synergy since the genes targeted by them (Gene A and Gene C) genetically interact with each other. On the other hand, Drug 1 and Drug 2 exhibit non-specific synergy since there is no genetic interaction between the genes targeted by them (Gene A and Gene B). Finally, an example is shown of two drugs (Drug 1 and Drug 4) that do not synergize with each other, and also do not show any genetic interaction between the genes they target (Gene A and Gene D).