Table 2.
Results of univariate analyses on incidence of neuropathy
| Hazard Ratio | p-value | |
|
| ||
| Overall substance use variables | ||
|
| ||
| Any substance usea | 1.48 | 0.02 |
|
| ||
| DSM-IV substance use disorder | 1.46 | 0.01 |
|
| ||
| History of intravenous drugs | 1.27 | 0.08 |
|
| ||
| Positive urine toxicology | 1.28 | 0.08 |
|
| ||
| Number of substancesb (continuous) | 1.17 | 0.009 |
| 1 | 1.25 | |
| 2–3 | 1.39 | |
| 4 or more | 1.61 | |
|
| ||
| Individual substance use variablec | ||
|
| ||
| Alcohol | 1.16 | 0.23 |
|
| ||
| Cannabis | 1.22 | 0.12 |
|
| ||
| Cocaine | 1.22 | 0.11 |
|
| ||
| Opiates | 1.23 | 0.17 |
|
| ||
| Sedatives | 1.25 | 0.20 |
|
| ||
| Demographic variables | ||
|
| ||
| Age | 1.01 | 0.13 |
|
| ||
| Gender | 1.01 | 0.95 |
|
| ||
| Ethnicityd | ||
| African-American | 1.14 | 0.38 |
| Hispanic | 0.77 | 0.10 |
| Other | 0.65 | 0.22 |
|
| ||
| HIV-related variables | ||
|
| ||
| HIV duration | 1.03 | 0.02 |
|
| ||
| Current use of d-drugs | .80 | 0.09 |
|
| ||
| Any history of d-drugs | 0.97 | 0.97 |
|
| ||
| Laboratory parameters | ||
|
| ||
| Serum glucose | 1.00 | 0.29 |
|
| ||
| CD4+ count | 1.00 | 0.76 |
|
| ||
| Hemoglobin | .93 | 0.04 |
|
| ||
| Log serum HIV viral load | 1.08 | 0.18 |
a
Includes DSM-IV substance use disorder, history of intravenous drug use as an HIV-risk factor, or positive urine toxicology
b
Defined as a DSM-IV diagnosis or urine toxicology positive for an individual substance
c
p-values were ≥.5 for all other individual substances
d
Used white as reference group.