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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Eur J Neurosci. 2012 Mar;35(6):805–825. doi: 10.1111/j.1460-9568.2012.08035.x

Figure 7. Connectivity of left M1 hand region, based on structural equation modeling of PET data after TMS.

Figure 7

TMS is applied to the left primary motor cortex, and blood flow changes examined with PET. The connectivity is determined using structural equation modeling in regions of interest based on the timing of activity changes in these different regions. The pink connections are the first order paths, where the TMS “signal” propagates immediately after motor cortex stimulation. The second-order paths, where the activity changes propagate from the first-order regions, are illustrated in green. The third order paths are shown in blue. Regions are as follows: LMI - Left primary sensorimotor cortex; LTHvpl - Left ventral posterolateral nucleus of the thalamus; LTHvl - Left ventral lateral nucleus of the thalamus; LPPC = Left posterior parietal cortex; LPMv - Left ventral premotor area; Cing - Cingulate gyrus; SMA - Supplementary motor area; RSII - Right secondary somatosensory Cortex; LSII - Left secondary somatosensory cortex; RTHvl - Right ventrolateral thalamus; Rcer - Right cerebellum. (Modified with permission from Laird et al, 2008)