Table 4.
Effect of dietary omega-3 fatty acids on ECG parameters at baseline and during coronary artery occlusion.
| Pre-treatment |
Post-treatment |
|||
|---|---|---|---|---|
| Control | Occlusion | Control | Occlusion | |
| HEART RATE (BEATS/MIN) | ||||
| VF+ | ||||
| Placebo | 125.6 ± 7.1 | 172.9 ± 13.6* | 124.6 ± 8.4 | 168.6 ± 16.4* |
| n−3 PUFA | 126.7 ± 5.1 | 163.9 ± 7.3* | 113.9 ± 4.3# | 147.3 ± 6.9*# |
| VF− | ||||
| Placebo | 122.8 ± 7.2 | 148.1 ± 12.9* | 125.4 ± 9.3 | 144.7 ± 10.3* |
| n−3 PUFA | 128.6 ± 4.7 | 146.7 ± 6.0* | 116.2 ± 4.1# | 139.4 ± 5.9* |
| PR INTERVAL (ms) | ||||
| VF+ | ||||
| Placebo | 91.2 ± 4.9 | 77.6 ± 6.2* | 98.8 ± 5.5 | 83.8 ± 2.6* |
| n−3 PUFA | 95.3 ± 3.5 | 87.1 ± 3.5* | 104.9 ± 3.4# | 96.8 ± 3.5*# |
| VF− | ||||
| Placebo | 99.6 ± 3.7 | 83.6 ± 4.2* | 102.3 ± 4.1 | 99.4 ± 5.0* |
| n−3 PUFA | 98.7 ± 3.4 | 88.6 ± 3.7* | 103.4 ± 3.2 | 95.4 ± 4.2* |
| QRS DURATION (ms) | ||||
| VF+ | ||||
| Placebo | 77.2 ± 4.3 | 78.2 ± 4.7 | 79.6 ± 3.9 | 79.1 ± 2.1 |
| n−3 PUFA | 82.8 ± 1.6 | 79.0 ± 2.1 | 82.0 ± 1.1 | 80.9 ± 1.6 |
| VF− | ||||
| Placebo | 83.4 ± 2.9 | 81.1 ± 2.9 | 88.3 ± 1.6 | 86.3 ± 2.0 |
| n−3 PUFA | 80.0 ± 1.9 | 79.4 ± 2.0 | 82.5 ± 1.5 | 82.1 ± 1.5 |
| QTc INTERVAL (ms) | ||||
| VF+ | ||||
| Placebo | 245.6 ± 5.0 | 248.0 ± 5.2 | 263.8 ± 5.4# | 250.7 ± 5.4 |
| n−3 PUFA | 256.2 ± 3.6 | 257.9 ± 5.8 | 272.4 ± 3.3# | 261.9 ± 3.6# |
| VF− | ||||
| Placebo | 251.0 ± 7.5 | 255.1 ± 5.4 | 278.0 ± 3.7# | 268.3 ± 5.4# |
| n−3 PUFA | 252.4 ± 3.1 | 248.6 ± 3.2 | 270.2 ± 3.9# | 268.3 ± 4.7# |
| TPEAK–TEND (CORRECTED; ms) | ||||
| VF+ | ||||
| Placebo | 89.1 ± 6.2 | 97.7 ± 6.3* | 87.11 ± 3.5 | 110.3 ± 7.3* |
| n−3 PUFA | 87.7 ± 3.2 | 103.6 ± 3.7* | 89.5 ± 2.9 | 105.4 ± 4.5* |
| VF− | ||||
| Placebo | 86.9 ± 4.5 | 92.7 ± 5.1 | 90.7 ± 4.8 | 91.3 ± 7.1 |
| n−3 PUFA | 88.6 ± 3.1 | 85.6 ± 4.6 | 89.0 ± 4.5 | 92.4 ± 4.6 |
*P < 0.01 control vs. coronary artery occlusion (60 s after occlusion onset); #P < 0.01 Pre-treatment vs. Post-treatment; n−3 PUFA, omega-3 polyunsaturated fatty acids.
Heart rate correction: QTc = QT − 87(60/HR − 1); Tpeak–Tend (corrected) = Tpeak–Tend − 87(60/HR − 1) (Van de Water et al., 1989); VF+, susceptible to ventricular fibrillation, VF−, resistant to ventricular fibrillation.