Table 1.
Analysis data for PMPMEase inhibition by FFAs and PGs
| FFAs/PGs | IC50 [μM] | Ki [μM] | |
|---|---|---|---|
| Octanoic acid | OcA | >1000 | >28 |
| Decanoic acid | DeA | >1000 | >28 |
| Lauric acid | LA | 230 | 6.5 |
| Myristic acid | MA | 100 | 2.8 |
| Palmitic acid | PA | >1000 | >28 |
| Stearic acid | STE | >1000 | >28 |
| Arachidic acid | ARA | >1000 | >28 |
| Myristoleic acid | MY | 63 | 1.8 |
| Palmitoleic acid | PA | 37 | 1.0 |
| Elaidic acid | EA | >1000 | >28 |
| Oleic acid | OA | 53 | 1.5 |
| Linoleic acid | LNA | 64 | 1.8 |
| Linolenic acid | LO | 22 | 0.62 |
| Arachidonic acid | AA | 6.6 | 0.12 |
| Eicosapentaenoic acid | EPA | 12 | 0.34 |
| Docosahexaenoic acid | DHA | 130 | 3.7 |
| Erucic acid | ER | >1000 | >28 |
| Prostaglandin A1 | PGA1 | >1000 | >28 |
| Prostaglandin A2 | PGA2 | 420 | 12 |
| Prostaglandin B1 | PGB1 | 580 | 16 |
| Prostaglandin E1 | PGE1 | >1000 | >28 |
| Prostaglandin E2 | PGE2 | >1000 | >28 |
| Prostaglandin F1β | PGF1β | >1000 | >28 |
| Prostaglandin F2α | PGF2α | >1000 | >28 |