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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Trends Endocrinol Metab. 2012 Feb 2;23(3):142–153. doi: 10.1016/j.tem.2011.12.008

Figure 7. Potential dynamic alterations in insulin sensitivity and redox environment as a function of metabolic balance over time.

Figure 7

Frequent intake of energy dense meals in conjunction with a sedentary lifestyle promotes acute and persistent fluctuations, positive metabolic balance, as well as concomitant shifts in both the redox environment and insulin sensitivity. Summation of these acute fluctuations over an extended period of time (1 week) result in a gradual shift in baseline levels for redox environment and insulin sensitivity, as well as exacerbated shifts in response to meal challenges, ultimately leading to relative insulin resistant state.