. 2011 Dec 15;35(1):153–158. doi: 10.1590/s1415-47572011005000060

Table 2.

Chromosome aberrations in metaphase CHO-K1 cells exposed to metformin.

Treatments	Examined cells (N)	Structural chromosome aberrations (%)			Total structural aberrations (%)	Number of damaged cells

		Breaks	Gaps	Acentric fragments
Negative control	400	0.50 ± 0.50	1.25 ± 1.06	2.75 ± 0.35	4.5 ± 0.00^a	18
Positive control	356	2.56 ± 1.35	-	9.24 ± 0.60	11.82 ± 0.74^b	42
Metformin 114.4 μg/mL	400	0.75 ± 0.35	0.75 ± 1.06	5.50 ± 0.70	6.50 ± 2.82^ab	28
Metformin 572.0 μg/mL	398	1.76 ± 1.07	0.25 ± 0.35	4.02 ± 0.73	6.03 ± 1.46^a	32

^{a, b}

Different superscripts in the same column denote significant differences (p < 0.05).