Table 3.
Micronuclei in polychromatic erythrocytes of Swiss mice treated with metformin*
| Treatments | MN – PCE (%) | PCE/NCE (%) |
|---|---|---|
| Negative control | 3.5 ± 2.70a | 45.51a |
| Positive control | 23.3 ± 12.80b | 34.88a |
| Metformin 95.4 mg/kg | 7.7 ± 7.20a | 46.11a |
| Metformin 190.8 mg/kg | 11.3 ± 10.30a | 46.03a |
MN: micronuclei; PCE: polychromatic erythrocytes; NCE: normochromatic erythrocytes
*
Metformin at concentrations of 334.7 mg/kg – there are no bone-marrow cells, probably as result of acute cytotoxicity.
a, b
Different superscripts in the same column denote significant differences (p < 0.05).