FIG. 1.
(a) Schematic of the remodeling chamber. With flow, modules packed against the retaining pillars while the interconnected void spaces between cylindrical modules facilitated percolation. Lc is the length of the packed module bed. (b) Modular constructs (i) experienced instantaneous compaction with flow (ii). The cells within the construct then remodeled this compacted mass (iii). Larger void spaces collapsed, and stratified module layers became apparent at day 21 (iii). Layers were oriented perpendicular to the incoming flow and spanned the width of the chamber, as shown. At later time points (14 and 21 days), portions of the modular tissue squeezed through the retaining pillars up to a depth of approximately 450 μm. Color images available online at www.liebertonline.com/tea