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. Author manuscript; available in PMC: 2013 Feb 6.
Published in final edited form as: Mol Pharm. 2012 Jan 20;9(2):325–333. doi: 10.1021/mp2005577

Figure 7.

Figure 7

Injection of Co(III)-Ci but not Co(III)-CiMut is able to partially rescue the effects of a genetic hh null in vivo. hh null embryos create Ci repressor (diagram A′) whereas a ci null will not (B′). These different genotypes result in distinct phenotypes. (A) Drosophila cuticle mounts showing the denticle belt patterning of 48 hour old (A) hh null and (B) ci94 (null) embryos. hh null embryos between 0 and 45 minutes old were microinjected with 1 μM (C) Co(III)-CiMut or (D) Co(III)-Ci, allowed to develop, mounted and imaged as previously. Arrow points to separation and patterning between denticle belts present in the ci null but never present in a hh null. (E) Percent of embryos that showed a rescue of denticle belt patterning. (* = p < 0.05)