TABLE 3.

Implications of Screening ECG and/or ECHO on PPV, NPV, Number Needed to Screen, False-Positives, and False-Negatives for Illustrative Points on the HSROC Curve

	Prevalence per 100 000	Sensitivity	Specificity	PPV	NPV	Number Needed to Screen to Detect 1 Case	Number of False-Positives When Detecting 1 Case	Number of False-Negatives per 100 000 Screened
Illustrative point where sensitivity and specificity are equally weighted (maximal accuracy) with prevalence from meta-analysis
HCM & ECG	45	0.847	0.848	0.0025 (1/400)	0.9999	2624	399	7
HCM & ECHO	45	0.851	0.851	0.0026 (1/390)	0.9999	2611	389	7
HCM & ECG/ECHO	45	0.837	0.837	0.0023 (1/434)	0.9999	2655	433	7
LQTS & ECG	7	0.861	0.860	0.0004 (1/2324)	0.9999	16 592	2323	1
WPW & ECG	136	1.000	1.000	1.0000	1.0000	735	0	0
Illustrative point where specificity is given more weight (maximal specificity) with prevalence from meta-analysis
HCM & ECG	45	0.039	0.999	0.0173 (1/58)	0.9996	56 980	57	43
HCM & ECHO	45	0.607	0.999	0.2146 (1/5)	0.9998	3661	4	18
HCM & ECG/ECHO	45	0.514	0.999	0.1879 (1/5)	0.9998	4323	4	22
LQTS & ECG	7	0.106	0.999	0.0074 (1/136)	0.9999	134 771	135	6
WPW & ECG	136	1.000	1.000	1.0000	1.0000	735	0	0
Illustrative point where sensitivity and specificity are equally weighted (maximal accuracy) with oft-cited prevalence
HCM & ECG	20019	0.847	0.848	0.0110 (1/91)	0.9996	590	90	31
HCM & ECHO	20019	0.851	0.851	0.0113 (1/88)	0.9996	588	87	30
HCM & ECG/ECHO	20019	0.837	0.837	0.0102 (1/98)	0.9996	597	97	33
LQTS & ECG	5013	0.861	0.860	0.0031 (1/326)	0.9999	2323	325	7
WPW & ECG	20020	1.000	1.000	1.0000	1.0000	500	0	0
Illustrative point where specificity is given more weight (maximal specificity) with oft-cited prevalence
HCM & ECG	20019	0.039	0.999	0.0725 (1/14)	0.9981	12 821	13	192
HCM & ECHO	20019	0.607	0.999	0.5488(1/2)	0.9992	824	1	79
HCM & ECG/ECHO	20019	0.514	0.999	0.5074 (1/2)	0.9990	973	1	97
LQTS & ECG	5013	0.106	0.999	0.0504 (1/20)	0.9996	18 868	19	45
WPW & ECG	20020	1.000	1.000	1.0000	1.0000	500	0	0

ECG/ECHO, ECG combined with ECHO.