TABLE 3.
Maternal and Neonatal Characteristics of VLBW Infants Who Survived >3 Days: Infants With MRSA Compared With Infants With MSSA B/M, NICHD NRN 2006–2008
| Characteristica | MRSA N = 88 | MSSA N = 228 | Pb |
|---|---|---|---|
| Mother’s age, y | |||
| Median (25th–75th percentile) | 25 (22–32) | 26 (21–32) | 0.7 |
| Antenatal antibiotic use during delivery admission, n (%) | 56 (64) | 118 (53) | 0.1 |
| Antenatal steroid use before delivery, n (%) | 74 (86) | 187 (82) | 0.5 |
| Chorioamnionitis noted in mother’s medical record, n (%) | 7 (8) | 11 (5) | 0.3 |
| Placental pathology performed, n (%) | 72 (83) | 163 (74) | 0.1 |
| Histologic chorioamnionitis,c n (%) | 22 (31) | 47 (29) | 0.8 |
| Cesarean section delivery, n (%) | 65 (74) | 159 (70) | 0.5 |
| Multiple births, n (%) | 24 (27) | 52 (23) | 0.5 |
| BW, g | |||
| Median (25th–75th percentile) | 780 (636–935) | 783 (646–1009) | 0.6 |
| Category, n (%) | |||
| 401–750 | 39 (44) | 100 (44) | |
| 751–1000 | 33 (38) | 70 (31) | |
| 1001–1250 | 8 (9) | 47 (21) | |
| 1251–1500 | 8 (9) | 11 (5) | |
| GA, wk | |||
| Median (25th–75th percentile) | 26 (24–28) | 26 (25–28) | 0.7 |
| Category, n (%) | |||
| <25 | 23 (26) | 52 (23) | |
| 25–28 | 52 (59) | 145 (64) | |
| 29+ | 13 (15) | 31 (14) | |
| SGA, n (%) | 14 (16) | 38 (17) | 1.0 |
| Boy, n (%) | 45 (51) | 127 (56) | 0.5 |
| Race/ethnicity, n (%) | 0.02d | ||
| Non-Hispanic black | 49 (56) | 85 (37) | |
| Non-Hispanic white | 28 (32) | 85 (37) | |
| Hispanic | 9 (10) | 48 (21) | |
| Other | 2 (2) | 10 (4) | |
| Major birth defect, n (%) | 5 (6) | 11 (5) | 0.8 |
| Total episodes of B/M,e n (%) | |||
| 1 | 52 (59) | 156 (68) | 0.1 |
| 2 | 26 (30) | 54 (24) | |
| 3 or more | 10 (11) | 18 (8) | |
| Any non-SA B/M,f n (%) | 45 (51) | 98 (43) | 0.3 |
| Timing of SA B/M, n (%) | 0.8 | ||
| Early onset | 1 (1) | 3 (1) | |
| Late onset | 87 (99) | 224 (98) | |
| Both early and late | 0 (0) | 1 (<1) | |
| SA infection site, n (%) | 0.1 | ||
| Blood | 82 (93) | 223 (98) | |
| CSF | 2 (2) | 1 (<1) | |
| Both blood and CSF | 4 (5) | 4 (2) |
Median values or the number and percent of infants with MRSA and of infants with MSSA who had each characteristic are shown.
Information was missing for antenatal antibiotics: from the mothers of 4 infants; antenatal steroids: 2; chorioamnionitis: 1; placental pathology performed: 8; histologic chorioamnionitis: 3.
P value for a test between infants with MRSA versus infants with MSSA by the Kruskal-Wallis test (median mother’s age, BW, GA), Fisher’s exact test, the row mean score χ2 test (number of episodes), or the general association χ2 test.
Percents are among infants with placental pathology performed.
P = .9 by the Cochran-Mantel-Haenszel χ2 test after controlling for study center.
Episodes were defined by positive cultures taken 5 or more days apart. Positive cultures taken within 4 days were considered indicative of the same episode. The 316 infants with SA had a total of 463 episodes of B/M.
B/M due to a pathogen other than SA on 1 or more episodes separate from B/M due to SA and/or a polymicrobial infection involving SA and a non-SA pathogen. Polymicrobial infections were reported for 73 infants (76 episodes).