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. 2011 Sep 28;86(1):3. doi: 10.1095/biolreprod.111.094367

FIG. 2.

FIG. 2.

The effects of reduced chromosome cohesion in MI. A–C) Chromosome arm cohesion distal to crossover sites holds bivalents together in MI (A). Loss of arm cohesion leads to a shift of chiasmata toward the distal end of chromosomes (B), and complete loss of arm cohesion results in premature complete separation of a bivalent (C). D–E) Centromere cohesion holds sister kinetochores together to facilitate mono-orientation (D), and a reduction of centromere cohesion promotes sister kinetochores to erroneously biorient at MI (E).