FIG. 4.

Effect of simvastatin (1 μM), GGPP (30 μM), and FPP (30 μM) on steroid production by theca-interstitial cells: progesterone (A), androstenedione (B), and androsterone (C). The cells were cultured in chemically defined media supplemented with LH (5 ng/ml) for 48 h in the absence (control) or in the presence of simvastatin and/or GGPP or FPP. Steroid levels were determined as described in Figure 2. Results are presented as a percentage of control. Each bar represents the mean ± SEM. Means with no superscripts in common are significantly different (P < 0.05).