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Outline of the mevalonate pathway. Conversion of acetoacetyl-coenzyme A to HMG-CoA to mevalonic acid is regulated by HMG-CoA reductase, the rate-limiting step of cholesterol synthesis. Statins competitively inhibit HMG-CoA reductase. FPP and GGPP are the intermediate downstream products of mevalonic acid. FPP is involved in farnesylation of proteins and is inhibited by FTI. GGPP is involved in geranylgeranylation of proteins and is inhibited by GGTI.
