TABLE 3.

Insulin response to graded glucose infusion in unoperated children with diffuse SUR1^−/− hyperinsulinism

	Peak blood glucose (mg/dl)	Peak plasma insulin (μU/ml)	Glucose sensitivity (μU · mg−1 · 10−2)	Insulin displacement at 150 mg/dl glucose (%)
SUR1−/− children
Patient 3	350	56	0	0
Patient 5	198	18	6	0
Patient 6	345	51	4	0
Mean ± SE	298 ± 50 (NS*)	42 ± 12 (P < 0.05)	4 ± 2 (P < 0.01)	0 ± 0 (P = 0.0001)
Adults (n = 9)
Mean ± SE	257 ± 15	120 ± 31	57 ± 13	47 ± 7
95% CI	223–292	48–191	27–86	32–63

^*Significance of the difference between the mean values of the children and adults by the alternate Welch t test.