Table 2.

Multivariate logistic regression analysis of rs2294008

			Genotype
		All	CC	CT	TT	Dominant	P-value	P for heterogeneity
Alla	Case/Control	5,038 / 9,363	1,288 / 2,842	2,613 / 4,668	1,137 / 1,853
	ORc (95% CI)		1	1.30 (1.18–1.42)	1.40 (1.25–1.56)	1.33 (1.22–1.45)	1.30 × 10−10	0.58
Male	Case/Control	4,159 / 5,104	1,080 / 1,576	2,147 / 2,500	932 / 1,028
	ORd (95% CI)		1	1.30 (1.17–1.44)	1.38 (1.21–1.56)	1.32 (1.20–1.45)	2.05 × 10−8	0.22
Female	Case/Control	871 / 3,558	205 / 1,037	464 / 1,827	202 / 694
	ORd (95% CI)		1	1.29 (1.06–1.58)	1.48 (1.16–1.88)	1.34 (1.11–1.62)	2.47 × 10−3	0.57
Never smoker	Case/Control	983 / 2,871	233 / 866	511 / 1,431	239 / 574
	ORe (95% CI)		1	1.41 (1.17–1.70)	1.54 (1.23–1.93)	1.45 (1.21–1.73)	5.50 × 10−5	0.30
Ever smoker	Case/Control	3,727 / 5,660	955 / 1719	1,938 / 2,825	834 / 1,116
	ORe (95% CI)		1	1.26 (1.13–1.39)	1.34 (1.18–1.52)	1.28 (1.16–1.41)	1.20 × 10−6	0.53
Age ≤ 62b	Case/Control	1,996 / 4,561	511 / 1,353	1,054 / 2,318	431 / 890
	ORc (95% CI)		1	1.24 (1.08–1.43)	1.35 (1.14–1.61)	1.27 (1.11–1.45)	4.20 × 10−4	0.87
Age > 62b	Case/Control	3,042 / 4,802	777 / 1,489	1,559 / 2,350	706 / 963
	ORc (95% CI)		1	1.33 (1.17–1.50)	1.44 (1.24–1.66)	1.36 (1.21–1.52)	1.41 × 10−7	0.52

^aExcludes Iceland, UK and Sweden populations owing to lack of individual epidemiologic data in controls.

^bAge cutoff is the median age in controls.

^cAdjusted for age, gender, smoking status and study site.

^dAdjusted for age, smoking status and study site.

^eAdjusted for age, gender and study site.