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. 2012 Jan 3;21(8):1760–1769. doi: 10.1093/hmg/ddr609

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© The Author 2012. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Locomotor contractions are less frequent in parkin larvae. (A) A larval extensometer, constructed from a flexible photobeam and quadrant photodiode. (B) Peristaltic waves recorded by the extensometer show that contractions are fewer in parkin knockouts than in wild-type, but the peak–peak excursion is not affected. (C) The mean force is the same in wild-type and parkin knockout (ANOVA: F_1,27 = 2.8, P= 0.10). (D) The frequency of peristaltic contractions is reduced in the parkin knockout (ANOVA, Bonferroni post hoc test, P< 0.001), and completely rescued by neuronal expression of wild-type parkin in nerve (Bonferroni post hoc test versus parkin P= 0.014; versus wild-type P= 0.56). Expression in muscle is ineffective (Bonferroni P= 0.38). Genotypes and number of larvae—wild-type: CS 13; parkin: park²⁵/park²⁵ 15; drivers: neuronal: elav^3EI 10; muscle: G14 12. Rescues are in park²⁵/park²⁵ background.