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. 2012 Jan 6;21(8):1782–1793. doi: 10.1093/hmg/ddr611

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Figure 4. — Increased proliferation at the NCC migration wavefront and reduced neuronal differentiation along the gut at E11.5 in Tcof1^+/− embryos. Immunostaining of E11.5 whole guts with p75 (red) and either pHH3 (green) or BrdU (green) revealed no difference in proliferation between genotypes along the intestines. Dividing cells can be identified by the presence of green staining in the nucleus. However, a significant increase in NCC proliferation at the migration wavefront was counted in Tcof1^+/− embryos compared with wild-type. Reduced neuronal differentiation was scored throughout the intestines in Tcof1^+/− compared with Tcof1^+/+ guts immunostained with p75 (red) and TuJ1 (green). *P < 0.05 (Student's t-test).