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Shh overexpression in E11.5 posterior limb buds of Gli3 mutant embryos is rescued in the absence of Zic3, as determined by real-time PCR. Expression of Shh is significantly increased in Gli3+/− and Gli3−/− posterior limb buds compared with WT (P < 0.0001, asterisks). The numbers of embryos studied were WT (n = 5), Zic3 null (n = 3), Gli3+/− (n = 4), Gli3−/− (n = 3), Zic3 null; Gli3+/− (n = 3) and Zic3 null; Gli3−/− (n = 3). Shh expression was normalized to Gapdh.
