Table 2.

miRNAs that influence PCa progression

miRNA	Role in PCa	Function	Study
miR-15a and miR-16	Tumor suppressors	Inhibit cell proliferation, invasion and angiogenesis through regulation of multiple targets	Aqeilan 2010 [25], Musumeci 2011[72]
miR-21	Onco-miRNA	Increases tumor growth, invasion and metastasis	Si 2007 [79], Selciklu 2009 [80], Li 2009 [81], Ribas 2009 [82]
miR-125b	Onco-miRNA	Increases cell proliferation and inhibits apoptosis	Lee 2005 [84], Shi 2007 [26], Vere White 2009 [85]
miR-143	Tumor suppressor	Inhibits cell proliferation and migration by regulating KRAS, MAPK pathways and cell cycle. Also inhibits metastasis	Clape 2009 [67], Xu 2011 [4], Friedman 2009 [73]
miR-145	Tumor suppressor	Inhibits migration, invasion and metastasis	Friedman 2009 [73]
miR-200 s	Tumor suppressor	Inhibit cell migration and invasion by reversing EMT	Kong 2009 and 2010 [69,70]
miR-221	Onco-miRNA	Stimulates cell growth and influences cell cycle progression	Zheng 2011 [78], Galardi 2007 [77], Sun 2009 [76], Pang 2010 [23].
miR-222	Onco-miRNA	Increased cell cycle progression	Galardi 2007 [77], Sun 2009 [76], Pang 2010 [23].
miR-488	Tumor suppressor	Inhibits Androgen Receptor-mediated cell growth	Sikand 2010 [75]