Table 1. Average sequence identity within and across the groups of Sec14 superfamily.
| Group-I | Group-IIA | Group-IIB | Group-III | NF1 | RhoGEFs | CRAL_TRIO | |
| Group-I | 64.8 (2278) | ||||||
| Group-IIA | 24.8 (2040) | 57.4 (435) | |||||
| Group-IIB | 24 (2244) | 28.1 (990) | 43.3 (528) | ||||
| Group-III | 33.4 (2788) | 30.6 (1230) | 24.2 (1353) | 49.8 (820) | |||
| NF1 | 15.1 (884) | 18.6 (390) | 16.9 (429) | 16.9 (533) | 36.4 (78) | ||
| RhoGEFs | 12.2 (1088) | 14.2 (480) | 12.1 (528) | 14.5 (656) | 12.9 (208) | 41.5 (120) | |
| CRAL_TRIO | 13.3 (4692) | 12.2 (2070) | 12.7 (2277) | 11.2 (2829) | 13.8 (897) | 14.9 (1104) | 21.4 (2346) |
The average sequence identity is given as calculated between all pairs of sequences. The numbers in bracket refers to the number of comparisons made in each group. The values are higher when compared within the group. The domains of NF1 and RhoGEF groups share comparable sequence similarity with BCH and with CRAL_TRIO domains. Thus, the domains of these proteins were referred as ‘BCH-like’.