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. 2012 Mar 27;7(3):e31680. doi: 10.1371/journal.pone.0031680

Figure 3. Normal systemic response to infection, but enhanced resistance to high dose per oral infection.

Figure 3

Expression of Pilrb (a) and Pilra(b) mRNA in the ileum of infected WT and Pilrb −/− mice at various timepoints after infection. Survival of WT and Pilrb−/− mice after high dose oral infection, n = 8–11 mice/group for each of 3 experiments performed (c). H&E of ileum sections from WT (top panels) and Pilrb−/− (lower panels), at day 0 (5×) or day 10 post-peroral challenge 5× and 20× magnification, respectively. Arrows indicate the presence of blood (d). Levels of cytokine protein present in the serum of naïve or infected mice at various timepoints, IL-12p70 (e) and IFNγ (f).