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. 2012 Mar 27;7(3):e34240. doi: 10.1371/journal.pone.0034240

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The pancreatic cancer pathway was reconstructed from Pancreatic Cancer Pathway (has:05212) in KEGG. Host factors are in red, including AKT1 (PKB/Akt), JAK1 (Jak1), and RELA (NF-κB). HIV protein Tat (in blue) interacted with AKT1 and NF-κB, activated the two proteins, and led to the expression of anti-apoptotic genes. The parallel solid lines represent the cell membrane. The dashed line represents the nuclear membrane.