Figure 2. Effects of short-term pretreatment with 10⁻⁸ M and 10⁻⁶ M ISV on glucagon secretion from palmitate-treated α-TC1–6 cells.

We studied glucagon secretion following 2-hour incubation with or without 0.5 mM palmitate in the presence or absence of 10⁻⁸ M and 10⁻⁶ M ISV in medium containing 18.0 mM glucose. Data is presented as mean ± SEM of 24 samples per group from three independent experiments. One-way ANOVA post hoc analyses: **P<0.01 vs. 18 mM glucose alone.