Table 3:

Adjusted^* association between atrial fibrillation and cognitive and functional outcomes for participants with stroke (previous or at follow-up) and without stroke

Outcome measures	No stroke, HR (95% CI) n = 23 665	Stroke (previous or at follow-up), HR (95% CI) n = 7 267	p value
Composite outcome†	1.21 (1.10–1.33)	1.18 (1.05–1.33)	0.5
Decrease in MMSE score ≥ 3	1.06 (0.93–1.20)	1.25 (1.06–1.47)	0.08
Dementia at follow-up	1.21 (1.01–1.45)	1.39 (1.13–1.71)	0.2
Loss of independence with ADL	1.26 (1.05–1.50)	1.42 (1.17–1.72)	0.8
Admission to long-term care	1.64 (1.34–2.00)	1.33 (1.04–1.69)	0.1

Note: ADL = activities of daily living, CI = confidence interval, HR = hazard ratio, MMSE = Mini–Mental State Examination.

^*Models were adjusted for the following confounding variables: age; level of education; sex; baseline MMSE score; systolic blood pressure at baseline; history of stroke or transient ischemic attack, hypertension, diabetes and myocardial infarction; levels of microalbuminuria, macroalbuminuria, and creatinine; treatment with statins, β-blockers, angiotensin-converting enzyme inhibitors, antiplatelet therapy or oral anticoagulants; changes in systolic blood pressure during follow-up; smoking; body mass index; level of physical activity; presence of sleep apnea; and alcohol consumption.

^†Decrease in MMSE score of 3 points or more, new diagnosis of dementia at follow-up, loss of independence with performing ADL and admission to a long-term care facility.