Table 1.
Fold-change >1.5 (p<0.05) in system-specific genes with in utero tobacco exposure
| ID | Gene | Fold- change | p-value |
|---|---|---|---|
| Hematological development | |||
| SOCS1 | suppressor of cytokine signaling 1 | −2.10 | 0.05 |
| AP3D1 | AP-3 complex subunit δ1 | −2.01 | 0.00 |
| ANXA1 | annexin A1 | −1.94 | 0.04 |
| CSF2RA | GMCSF receptor/CD116 | −1.94 | 0.03 |
| SYK | spleen tyrosine kinase | −1.86 | 0.04 |
| CST3 | cystatin 3 | −1.79 | 0.04 |
| KLF13 | Kruppel-like factor 13 | −1.77 | 0.02 |
| CDK6 | cyclin-dependent kinase 6 | −1.71 | 0.03 |
| WASL | Wiskott-Aldrich syndrome gene-like | −1.67 | 0.00 |
| MLLT10 | leukemia AF-10 protein | −1.64 | 0.02 |
| LMAN1 | lectin mannose-binding 1 | −1.63 | 0.05 |
| TOP2A | DNA topoisomerase 2α | −1.63 | 0.02 |
| NF1 | neurofibromin 1 | −1.62 | 0.01 |
| AKT2 | RACβ serine/threonine-protein kinase | −1.60 | 0.01 |
| PTGS2 | cyclooxygenase-2 | −1.59 | 0.04 |
| CD8B | cluster of differentiation 8B | −1.58 | 0.02 |
| KLK3 | prostate-specific antigen | −1.57 | 0.05 |
| IFNK | interferon κ | −1.56 | 0.01 |
| SLC19A1 | folate transporter 1 | −1.55 | 0.04 |
| TSC2 3 | TSC22 domain family protein 3 | −1.55 | 0.04 |
| PIK3R1 | phosphatidylinositol 3-kinase regulatory subunit α | −1.53 | 0.01 |
| BCL3 | B-cell lymphoma 3-encoded protein | −1.51 | 0.01 |
| CREB1 | cAMP responsive element binding protein 1 | −1.51 | 0.02 |
| PALLD | palladin | −1.51 | 0.03 |
| IL9R | interleukin 9 receptor | 1.51 | 0.02 |
| CSNK1A1 | casein kinase I isoform α | 1.53 | 0.01 |
| IL23A | interleukin-23 subunit α | 1.53 | 0.00 |
| PTK2 | focal adhesion kinase | 1.62 | 0.02 |
| ITGB1 | integrin β1 | 1.67 | 0.02 |
| SMARCC1 | SWI/SNF complex subunit/BAF155 | 1.67 | 0.04 |
| PR47 | 47 kDa platelet receptor for type III collagen | 1.69 | 0.04 |
| EBI3 | Epstein-Barr virus induced gene 3 | 1.72 | 0.05 |
| PDPN | podoplanin | 1.76 | 0.01 |
| STAT5B | signal transducer and activator of transcription 5B | 1.94 | 0.04 |
| LCAT | lecithin-cholesterol acyltransferase | 1.96 | 0.03 |
| Musculoskeletal development | |||
| SOCS1 | suppressor of cytokine signaling 1 | −2.10 | 0.05 |
| ANXA1 | annexin A1 | −1.94 | 0.04 |
| NOX1 | NADPH oxidase 1 | −1.76 | 0.02 |
| FOSL2 | Fos-related antigen 2 | −1.64 | 0.00 |
| IGFBP5 | insulin-like growth factor-binding protein 5 | −1.64 | 0.01 |
| NF1 | neurofibromin 1 | −1.62 | 0.01 |
| ADRA1A | α1A adrenergic receptor | −1.60 | 0.05 |
| AKT2 | RACβ serine/threonine-protein kinase | −1.60 | 0.01 |
| PTGS2 | cyclooxygenase-2 | −1.59 | 0.04 |
| ABCC4 | ATP-binding cassette sub-family C member 4 | −1.58 | 0.00 |
| KLK3 | prostate-specific antigen | −1.57 | 0.05 |
| PIK3R1 | phosphatidylinositol 3-kinase regulatory subunit α | −1.53 | 0.01 |
| BCL3 | B-cell lymphoma 3-encoded protein | −1.51 | 0.01 |
| CREB1 | cAMP responsive element binding protein 1 | −1.51 | 0.02 |
| IL23A | interleukin-23 subunit alpha | 1.53 | 0.00 |
| PTK2 | focal adhesion kinase | 1.62 | 0.02 |
| ITGB1 | integrin β1 | 1.67 | 0.02 |
| STAT5B | signal transducer and activator of transcription 5B | 1.94 | 0.04 |
| Cardiovascular development | |||
| ANXA1 | annexin A1 | −1.94 | 0.04 |
| NOX1 | NADPH oxidase 1 | −1.76 | 0.02 |
| ADRA1A | α1A adrenergic receptor | −1.60 | 0.05 |
| PTGS2 | cyclooxygenase-2 | −1.59 | 0.04 |
| KLK3 | prostate-specific antigen | −1.57 | 0.05 |
| GLRX3 | glutaredoxin-3 | −1.53 | 0.03 |
| PTK2 | focal adhesion kinase | 1.62 | 0.02 |
| ITGB1 | integrin β1 | 1.67 | 0.02 |
| Neurological development | |||
| FKBP5 | FK506-binding protein 5 | −3.86 | 0.00 |
| ARHGAP32 | Rho GTPase-activating protein 32 | −1.95 | 0.04 |
| ANK2 | ankyrin 2, neuronal | −1.94 | 0.04 |
| DOCK1 | dedicator of cytokinesis, 180 kDa | −1.90 | 0.02 |
| FAM126A | family with sequence similarity 126, member A | −1.90 | 0.02 |
| NTRK2 | TrkB receptor | −1.84 | 0.04 |
| STX3 | syntaxin 3 | −1.81 | 0.03 |
| MAP6 | microtubule-associated protein 6 | −1.75 | 0.05 |
| FKBP4 | FK506-binding protein 4 | −1.70 | 0.01 |
| UNC13A | unc-13 homolog A | −1.66 | 0.03 |
| KCNJ5 | G protein-activated inward rectifier K+ channel 4/5 | −1.64 | 0.03 |
| NF1 | neurofibromin 1 | −1.62 | 0.01 |
| CREB1 | cAMP responsive element binding protein 1 | −1.51 | 0.02 |
| PALLD | palladin | −1.51 | 0.03 |
| LAMA5 | laminin subunit α5 | 1.56 | 0.04 |
| PTK2 | focal adhesion kinase | 1.62 | 0.02 |
| ITGB1 | integrin β1 | 1.67 | 0.02 |
| ARHGEF10 | Rho guanine nucleotide exchange factor 10 | 1.78 | 0.02 |
| CDC42BPA | serine/threonine-protein kinase MRCKα | 1.79 | 0.00 |