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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Acta Biomater. 2012 Feb 8;8(5):1685–1692. doi: 10.1016/j.actbio.2012.01.036

Figure 1.

Figure 1

Chemical structures and nanofiber self-assembly of PA molecules. The chemical structure of the GLP-1-mimetic PA (a) and the control PA (d) are identical except for the inclusion of the bioactive epitope Ser[2]exendin(1–9) at the N-terminus of the GLP-1-mimetic PA. The morphology of GLP-1-mimetic PA nanofibers (b) and control PA nanofibers (e) dissolved at 1mM in saline with 1mM calcium chloride was visualized by cryogenic TEM. The self-assembly of the GLP-1-mimetic PA into nanofibers stabilizes the α-helical conformation of the mimetic peptide (c). Please reproduce in color on the web and in print.